Developmental origins of accelerated cardiovascular aging

Developmental Origins of Cardiovascular Disease

ardiovascular risk factors are identifiable in childhood and are predictive of adulthood risk for coronary artery disease.1 Autopsy studies of youths have established a strong association between cardiovascular risk factors and early stages of coronary atherosclerosis.2 Longitudinal observation studies have shown that coronary heart disease (CHD) risk factors measured in adolescence predict mar...

Sex differences in the developmental origins of cardiovascular disease.

The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to th...

Accelerated Heat Aging Study of Phenolic/Basalt Fiber Reinforced Composites

One of the greatest impediments to use polymer-matrix composites is their susceptibility to degradation when exposed to the elevated temperatures and the limited knowledge on the thermal and mechanical properties of these composites at such temperatures. The objective of this study is to evaluate the effects of accelerated heat aging on the tensile properties of the Woven Basalt/Phenolic (WBP) ...

The origins of the developmental origins theory.

Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England an...

Mitophagy: New Insight into the Cardiovascular Aging